有哪些信誉好的足球投注网站analysis of tp53 codon 72 polymorphisms, tp53 mutations, and hpv infection in cutaneous squamous cell carcinomas分析tp53 72密码子多态性,tp53突变,和人乳头状瘤病毒感染皮肤鳞状细胞癌.pdfVIP
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analysis of tp53 codon 72 polymorphisms, tp53 mutations, and hpv infection in cutaneous squamous cell carcinomas分析tp53 72密码子多态性,tp53突变,和人乳头状瘤病毒感染皮肤鳞状细胞癌
Analysis of Tp53 Codon 72 Polymorphisms, Tp53
Mutations, and HPV Infection in Cutaneous Squamous
Cell Carcinomas
1,2 3¤ 3 2 2
Keith R. Loeb , Maryam M. Asgari , Stephen E. Hawes , Qinghua Feng , Joshua E. Stern ,
7 2,4 6 2,5
Mingjun Jiang , Zsolt B. Argenyi , Ethel-Michele de Villiers , Nancy B. Kiviat *
1 Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Department of Pathology, University of
Washington School of Medicine, Seattle, Washington, United States of America, 3 Department of Epidemiology, University of Washington School of Medicine, Seattle,
Washington, United States of America, 4 Division of Dermatology, University of Washington School of Medicine, Seattle, Washington, United States of America,
5 Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, 6 Division for the Characterization of
Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany, 7 Institute of Dermatology, National Academy of Medical Sciences, Nanjing, People’s Republic of
China
Abstract
Background: Non-melanoma skin cancers are one of the most common human malignancies accounting for 2–3% of
tumors in the US and represent a significant health burden. Epidemiology studies have implicated Tp53 mutations triggered
by UV exposure, and human papilloma virus (HPV) infection to be significant causes of non-melanoma skin cancer.
However, the relationship between Tp53 and cutaneous HPV infection is not wel
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