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analysis of the role of igf2 in adrenal tumour development in transgenic mouse modelsigf2的角色分析肾上腺肿瘤发展转基因小鼠模型
Analysis of the Role of Igf2 in Adrenal Tumour
Development in Transgenic Mouse Models
1,2,3 1,2,3. 4,5,6. ´ ´ 4,5,6
Coralie Drelon , Annabel Berthon , Bruno Ragazzon , Frederique Tissier ,
Roberto Bandiera7, Isabelle Sahut-Barnola1,2,3, Cyrille de Joussineau1,2,3, Marie Batisse-Lignier1,2,3,8,
1,2,3 ´ ˆ 4,5,6 1,2,3 1,2,3
Anne-Marie Lefranc¸ois-Martinez , Jerome Bertherat , Antoine Martinez , Pierre Val *
´ ´ ` `
1 Clermont Universite, Universite Blaise Pascal, GReD, Clermont-Ferrand, France, 2 CNRS UMR 6293, GReD, Aubiere, France, 3 Inserm U1103, GReD, Aubiere, France,
´ ˆ ˆ
4 Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France, 5 Inserm U1016, Paris, France, 6 Assistance Publique Hopitaux de Paris, Hopital Cochin,
Department of Endocrinology, Reference Center for Rare Adrenal Diseases, Paris, France, 7 Inserm UMR636, Nice, France, 8 Centre Hospitalier Universitaire, Service
´ ´
d’Endocrinologie, Faculte de Medecine, Clermont-Ferrand, France
Abstract
Adrenal cortical carcinomas (ACC) are rare but aggressive tumours associated with poor prognosis. The two most frequent
alterations in ACC in patients are overexpression of
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