an examination of kcne1 mutations and common variants in chronic tinnitus考试kcne1基因突变和常见变异的慢性耳鸣.pdfVIP

an examination of kcne1 mutations and common variants in chronic tinnitus考试kcne1基因突变和常见变异的慢性耳鸣.pdf

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an examination of kcne1 mutations and common variants in chronic tinnitus考试kcne1基因突变和常见变异的慢性耳鸣

Genes 2010, 1, 23-37; doi:10.3390/genes1010023 OPEN ACCESS genes ISSN 2073-4425 /journal/genes Article An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus Philipp G. Sand 1,*, Alexander Luettich 2, Tobias Kleinjung 3, Goeran Hajak 1 and 1 Berthold Langguth 1 Department of Psychiatry, University of Regensburg, Universitaetsstr. 84, 93042 Regensburg, Germany; E-Mails: goeran.hajak@medbo.de (G.H.); berthold.langguth@medbo.de (B.L.) 2 Experimental and Clinical Neurosciences Graduate Program, University of Regensburg, Germany; E-Mail: alexander.luettich@stud.uni-regensburg.de (A.L.) 3 Department of Otorhinolaryngology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; E-Mail: tobias.kleinjung@klinik.uni-regensburg.de (T.K.) * Author to whom correspondence should be addressed; E-Mail: philipp.sand@klinik.uni-regensburg.de; Tel.: +49-941-944-8955; Fax: +49-941-944-8956. Received: 29 March 2010; in revised form: 23 April 2010 / Accepted: 27 April 2010 / Published: 28 April 2010 Abstract: Chronic tinnitus is a highly prevalent and often incapacitating condition frequently associated with sensorineural hearing loss. While its etiology remains incompletely understood there is a growing awareness of genetic factors that predispose to, or aggravate chronic tinnitus. Candidate genes for the disorder include KCNE1, a potassium channel subunit gene that has been implicated in maturation defects

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