altered effective connectivity network of the amygdala in social anxiety disorder a resting-state fmri study杏仁核的改变有效连接网络社交焦虑症静息状态功能磁共振成像研究.pdfVIP

Altered Effective Connectivity Network of the Amygdala in Social Anxiety Disorder: A Resting-State fMRI Study 1. 2. 3 4 1 1 Wei Liao , Changjian Qiu , Claudio Gentili , Martin Walter , Zhengyong Pan , Jurong Ding , Wei 2 5 1 Zhang , Qiyong Gong *, Huafu Chen * 1 Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China, 2 Mental Health Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of China, 3 Unit of Clinical Psychology, AUO Pisa, Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Pisa, Italy, 4 Clinical Affective Neuroimaging Laboratory, Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany, 5 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, West China School of Medicine, Chengdu, People’s Republic of China Abstract The amygdala is often found to be abnormally recruited in social anxiety disorder (SAD) patients. The question whether amygdala activation is primarily abnormal and affects other brain systems or whether it responds ‘‘normally’’ to an abnormal pattern of information conveyed by other brain structures remained unanswered. To address this question, we investigated a network of effective connectivity associated with the amygdala using Granger causality analysis on resting-state functional MRI data of 22 SAD patients and 21 healthy controls (HC). Implications of abnormal effective connectivity and clinical severity were investigated