有哪些信誉好的足球投注网站adeno-associated viral vector-mediated transgene expression is independent of dna methylation in primate liver and skeletal muscle腺相关病毒vector-mediated转基因表达独立于dna甲基化在灵长类动物肝脏和骨骼肌.pdfVIP
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adeno-associated viral vector-mediated transgene expression is independent of dna methylation in primate liver and skeletal muscle腺相关病毒vector-mediated转基因表达独立于dna甲基化在灵长类动物肝脏和骨骼肌
Adeno-Associated Viral Vector-Mediated Transgene
Expression Is Independent of DNA Methylation in
Primate Liver and Skeletal Muscle
´ 1 1,2 3 3 4
Adrien Leger , Caroline Le Guiner , Michael L. Nickerson , Kate McGee Im , Nicolas Ferry , Philippe
1,2,5 1,5,6 1
Moullier , Richard O. Snyder , Magalie Penaud-Budloo *
´ ´
1 INSERM UMR649, Nantes, France, 2 Genethon, Evry, France, 3 National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America,
4 INSERM UMR948, Nantes, France, 5 Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of
America, 6 Center of Excellence for Regenerative Health Biotechnology, University of Florida, Alachua, Florida, United States of America
Abstract
Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues.
Intramuscular (IM) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak
protein level at 2–3 months, followed by a decrease over several months before reaching a steady-state. To investigate
transgene expression and vector genome persistence, we previously demonstrated that rAAV vector genomes associate
with histones and form a chromatin structure in NHP skeletal muscle more than one year after injection. In the mammalian
nucleus, chromatin remodeling via epigenetic modifications plays key role in transcriptional regulation. Among those, CpG
hyper-methylation of
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