adcc develops over time during persistent infection with live-attenuated siv and is associated with complete protection against sivmac251 challengeadcc发展随着时间的推移,在持续的感染猴免疫缺陷病毒减毒活疫苗和与完整保护sivmac251挑战.pdfVIP
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adcc develops over time during persistent infection with live-attenuated siv and is associated with complete protection against sivmac251 challengeadcc发展随着时间的推移,在持续的感染猴免疫缺陷病毒减毒活疫苗和与完整保护sivmac251挑战
ADCC Develops Over Time during Persistent Infection
with Live-Attenuated SIV and Is Associated with
Complete Protection against SIVmac251 Challenge
1 1 1 2
Michael D. Alpert , Jackson D. Harvey , W. Anderson Lauer , R. Keith Reeves , Michael Piatak
3 4 4 3 5 1
Jr. , Angela Carville , Keith G. Mansfield , Jeffrey D. Lifson , Wenjun Li , Ronald C. Desrosiers ,
2,6 1
R. Paul Johnson , David T. Evans *
1 Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of
America, 2 Immunology Division, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America, 3 SAIC
Frederick, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, 4 Department of Pathology, Harvard Medical School, New England Primate
Research Center, Southborough, Massachusetts, United States of America, 5 University of Massachusetts Medical School, Worcester, Massachusetts, United States of
America, 6 Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, and Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts,
United States of America
Abstract
Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent sterilizing immunity against
pathogenic SIV challenge in rhesus macaques. Understanding the mechanisms of protection by live-attenuated SIV may
provide important insights into the immune responses ne
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