有哪些信誉好的足球投注网站adam2 interactions with mouse eggs and cell lines expressing α4α9 (itga4itga9) integrins implications for integrin-based adhesion and fertilizationadam2与鼠标交互鸡蛋和细胞系表达α4α9(itga4itga9)整合蛋白影响integrin-based粘附和受精.pdfVIP
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adam2 interactions with mouse eggs and cell lines expressing α4α9 (itga4itga9) integrins implications for integrin-based adhesion and fertilizationadam2与鼠标交互鸡蛋和细胞系表达α4α9(itga4itga9)整合蛋白影响integrin-based粘附和受精
ADAM2 Interactions with Mouse Eggs and Cell Lines
Expressing a4/a9 (ITGA4/ITGA9) Integrins: Implications
for Integrin-Based Adhesion and Fertilization
Ulyana V. Desiderio, Xiaoling Zhu, Janice P. Evans*
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Abstract
Background: Integrins are heterodimeric cell adhesion molecules, with 18 a (ITGA) and eight b (ITGB) subunits forming 24
heterodimers classified into five families. Certain integrins, especially the a /a (ITGA4/ITGA9) family, interact with members
4 9
of the ADAM (a disintegrin and metalloprotease) family. ADAM2 is among the better characterized and also of interest
because of its role in sperm function. Having shown that ITGA9 on mouse eggs participates in mouse sperm-egg
interactions, we sought to characterize ITGA4/ITGA9-ADAM2 interactions.
Methodology/Principal Findings: An anti-b /ITGB1 function-blocking antibody that reduces sperm-egg binding
1
significantly inhibited ADAM2 binding to mouse eggs. Analysis of integrin subunit expression indicates that mouse eggs
could express at least ten different integrins, five in the RGD-binding family, two in the laminin-binding family, two in the
collagen-binding family, and ITGA9-ITGB1. Adhesion assays to characterize ADAM2 interactions with ITGA4/ITGA9 family
members produced the surprising result that RPMI 8866 cell adhesion to ADAM2 was inhibited by an anti-ITGA9 antibody,
noteworthy because ITGA9 has only been reported to dimerize with ITGB1, and RPMI 8866 cells lack detectable IT
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