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adaptation of high-throughput screening in drug discovery—toxicological screening tests适应大规模筛选的药物discovery-toxicological筛查
Int. J. Mol. Sci. 2012, 13, 427-452; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Adaptation of High-Throughput Screening in Drug
Discovery—Toxicological Screening Tests
Paweł Szymański, Magdalena Markowicz * and Elżbieta Mikiciuk-Olasik
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lodz,
Muszyńskiego 1, Lodz 90-151, Poland; E-Mails: pawel.szymanski@umed.lodz.pl (P.S.);
elzbieta.mikiciuk-olasik@umed.lodz.pl (E.M.-O.)
* Author to whom correspondence should be addressed;
E-Mail: magdalena.markowicz@umed.lodz.pl; Tel./Fax: +48-42-677-92-50.
Received: 16 September 2011; in revised form: 11 December 2011 / Accepted: 19 December 2011 /
Published: 29 December 2011
Abstract: High-throughput screening (HTS) is one of the newest techniques used in drug
design and may be applied in biological and chemical sciences. This method, due to
utilization of robots, detectors and software that regulate the whole process, enables a
series of analyses of chemical compounds to be conducted in a short time and the affinity
of biological structures which is often related to toxicity to be defined. Since 2008 we have
implemented the automation of this technique and as a consequence, the possibility to
examine 100,000 compounds per day. The HTS method is more frequently utilized
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