有哪些信誉好的足球投注网站adam17 deletion in thymic epithelial cells alters aire expression without affecting t cell developmental progressionadam17删除在胸腺上皮细胞改变涂画或表达而不影响t细胞的发育进程.pdfVIP
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adam17 deletion in thymic epithelial cells alters aire expression without affecting t cell developmental progressionadam17删除在胸腺上皮细胞改变涂画或表达而不影响t细胞的发育进程
ADAM17 Deletion in Thymic Epithelial Cells Alters Aire
Expression without Affecting T Cell Developmental
Progression
1 1 2 1
David M. Gravano , Bryce T. McLelland , Keisuke Horiuchi , Jennifer O. Manilay *
1 School of Natural Sciences, University of California at Merced, Merced, California, United States of America, 2 Department of Orthopedic Surgery and Department of
Anti-aging Orthopedic Research, School of Medicine, Keio University, Tokyo, Japan
Abstract
Background: Cellular interactions between thymocytes and thymic stromal cells are critical for normal T cell development.
Thymic epithelial cells (TECs) are important stromal niche cells that provide essential growth factors, cytokines, and present
self-antigens to developing thymocytes. The identification of genes that mediate cellular crosstalk in the thymus is ongoing.
One candidate gene, Adam17, encodes a metalloprotease that functions by cleaving the ectodomain of several
transmembrane proteins and regulates various developmental processes. In conventional Adam17 knockout mice, a non-
cell autonomous role for ADAM17 in adult T cell development was reported, which strongly suggested that expression of
ADAM17 in TECs was required for normal T cell development. However, knockdown of Adam17 results in multisystem
developmental defects and perinatal lethality, which has made study of the role of Adam17 in specific cell types difficult.
Here, we examined T cell and thymic epithelial cell development using a conditional knockout approach.
Methodology/Principal Findings: We generated an Adam17 conditional knockout mouse in which floxed Adam17 is
deleted specifically in TECs by Cre recombinase under t
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