acute podocyte vascular endothelial growth factor (vegf-a) knockdown disrupts alphavbeta3 integrin signaling in the glomerulus急性足突细胞血管内皮生长因子(vegf-a)击倒扰乱alphavbeta3肾小球的信号转导.pdfVIP

下载本文档

5
0
约8.26万字
约 13页
2017-09-07 发布于上海
举报
版权申诉

acute podocyte vascular endothelial growth factor (vegf-a) knockdown disrupts alphavbeta3 integrin signaling in the glomerulus急性足突细胞血管内皮生长因子(vegf-a)击倒扰乱alphavbeta3肾小球的信号转导.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

acute podocyte vascular endothelial growth factor (vegf-a) knockdown disrupts alphavbeta3 integrin signaling in the glomerulus急性足突细胞血管内皮生长因子(vegf-a)击倒扰乱alphavbeta3肾小球的信号转导

Acute Podocyte Vascular Endothelial Growth Factor (VEGF-A) Knockdown Disrupts alphaVbeta3 Integrin Signaling in the Glomerulus 1 2 1 1 3 Delma Veron , Guillermo Villegas , Pardeep Kumar Aggarwal , Claudia Bertuccio , Juan Jimenez , 4 2 5 6 6 Heino Velazquez , Kimberly Reidy , Dale R. Abrahamson , Gilbert Moeckel , Michael Kashgarian , Alda Tufro1* 1 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America, 2 Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America, 3 Analytical Imaging Facility, Albert Einstein College of Medicine, Bronx, New York, United States of America, 4 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, 5 Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, 6 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America Abstract Podocyte or endothelial cell VEGF-A knockout causes thrombotic microangiopathy in adult mice. To study the mechanism involved in acute and local injury caused by low podocyte VEGF-A we developed an inducible, podocyte-specific VEGF-A knockdown mouse, and we generated an immortalized podocyte cell line (VEGFKD) that downregulates VEGF-A upon doxycycline exposure. Tet-O-siVEGF:podocin-rtTA mice express VEGF shRNA in podocytes in a doxycycline-regulated manner, decreasing VEGF-A mRNA and VEGF-A protein levels in isolated glomeruli to ,20