有哪些信誉好的足球投注网站activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma激活的神经和多能干细胞签名与增加人类神经胶质瘤恶性肿瘤.pdfVIP
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activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma激活的神经和多能干细胞签名与增加人类神经胶质瘤恶性肿瘤
Activation of Neural and Pluripotent Stem Cell
Signatures Correlates with Increased Malignancy in
Human Glioma
1,2. 3. 4 3 ¨ 5 3
Johan Holmberg *, Xiaobing He , Inti Peredo , Abiel Orrego , Goran Hesselager , Christer Ericsson ,
6 7 7 ´ 3 1,2
Outi Hovatta , Sueli Mieko Oba-Shinjo , Suely Kazue Nagahashi Marie , Monica Nister , Jonas Muhr *
1 Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden, 2 Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden,
3 Department of Oncology-Pathology, Karolinska Institutet, CCK R8:05, Karolinska University Hospital Solna, Stockholm, Sweden, 4 Department of Clinical Neuroscience,
Neurosurgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, 5 Department of Neuroscience, Neurosurgery, Uppsala University, University
Hospital, Uppsala, Sweden, 6 Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm,
˜
Sweden, 7 Department of Neurology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Abstract
The presence of stem cell characteristics in glioma cells raises the possibility that mechanisms promoting the maintenance
and self-renewal of tissue specific stem cells have a similar function in tumor cells. Here we characterized human gliomas of
various malignancy grades for the expression of stem cell regulatory proteins. We show that
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