a vaccine encoding conserved promiscuous hiv cd4 epitopes induces broad t cell responses in mice transgenic to multiple common hla class ii molecules守恒的滥交的艾滋病毒疫苗编码cd4抗原表位诱导转基因老鼠广泛的t细胞的反应到多个常见hla分子ii级.pdfVIP

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a vaccine encoding conserved promiscuous hiv cd4 epitopes induces broad t cell responses in mice transgenic to multiple common hla class ii molecules守恒的滥交的艾滋病毒疫苗编码cd4抗原表位诱导转基因老鼠广泛的t细胞的反应到多个常见hla分子ii级.pdf

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a vaccine encoding conserved promiscuous hiv cd4 epitopes induces broad t cell responses in mice transgenic to multiple common hla class ii molecules守恒的滥交的艾滋病毒疫苗编码cd4抗原表位诱导转基因老鼠广泛的t细胞的反应到多个常见hla分子ii级

A Vaccine Encoding Conserved Promiscuous HIV CD4 Epitopes Induces Broad T Cell Responses in Mice Transgenic to Multiple Common HLA Class II Molecules Susan Pereira Ribeiro1,3., Daniela Santoro Rosa1,3., Simone Gonc¸alves Fonseca1,2, Eliane Conti 2,3 ´ 2,3 4 2,3 1,2,3 Mairena , Edilberto Postol , Sergio Costa Oliveira , Luiza Guilherme , Jorge Kalil , Edecio Cunha-Neto1,2,3* ˜ 1 Laboratory of Clinical Immunology and Allergy-LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, ˜ ˜ ˜ ˜ Sao Paulo, Brazil, 2 Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil, 3 Institute for Investigation in Immunology-INCT, Sao Paulo, Brazil, 4 Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil Abstract Current HIV vaccine approaches are focused on immunogens encoding whole HIV antigenic proteins that mainly elicit cytotoxic CD8+ responses. Mounting evidence points toward a critical role for CD4+ T cells in the control of immunodeficiency virus replication, probably due to cognate help. Vaccine-induced CD4+ T cell responses might, therefore, have a protective effect in HIV replication. In addition, successful vaccines may have to elicit responses to multiple epitopes in a high proportion of vaccinees, to match the highly variable ci