a viral nanoparticle with dual function as an anthrax antitoxin and vaccine病毒纳米颗粒具有双重功能作为炭疽抗毒素和疫苗.pdfVIP

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a viral nanoparticle with dual function as an anthrax antitoxin and vaccine病毒纳米颗粒具有双重功能作为炭疽抗毒素和疫苗.pdf

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a viral nanoparticle with dual function as an anthrax antitoxin and vaccine病毒纳米颗粒具有双重功能作为炭疽抗毒素和疫苗

A Viral Nanoparticle with Dual Function as an Anthrax Antitoxin and Vaccine 1 2 2 1 1 3 Darly J. Manayani , Diane Thomas , Kelly A. Dryden , Vijay Reddy , Marc E. Siladi , John M. Marlett , G. Jonah A. Rainey3 1 3 1,2,4 3 , Michael E. Pique , Heather M. Scobie , Mark Yeager , John A. T. Young , 2 1* Marianne Manchester , Anette Schneemann 1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, California , United States of America, 2 Department of Cell Biology, The Scripps Research Institute, La Jolla, California , United States of America, 3 The Salk Institute for Biological Studies, La Jolla, California, United States of America, 4 Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California, United States of America The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B. anthracis produces an AB-type toxin composed of the receptor-binding moiety protective antigen (PA) and the enzymatic moieties edema factor and lethal factor. PA is a key target for both antitoxin and vaccine development. We used the icosahedral insect virus Flock House virus as a platform to display 180 copies of the high affinity, PA-binding von Willebrand A domain of the ANTXR2 cellular receptor. The chimeric virus- like particles (VLPs) correctly displayed the receptor von Willebrand A domain on their surface and inhibited lethal toxin action in in vitro and in vivo models of anthrax intoxication. Moreover, VLPs complexed with PA elicited a potent toxin-neutralizing antibody response that