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a signaling network for patterning of neuronal connectivity in the drosophila brain信号网络模式果蝇大脑的神经连接
PLoS BIOLOGY
A Signaling Network for Patterning
of Neuronal Connectivity
in the Drosophila Brain
1 1 1 2 2 1*
Mohammed Srahna , Maarten Leyssen , Ching Man Choi , Lee G. Fradkin , Jasprina N. Noordermeer , Bassem A. Hassan
1 Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven School
of Medicine, Leuven, Belgium, 2 Laboratory of Developmental Neurobiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
The precise number and pattern of axonal connections generated during brain development regulates animal
behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to
achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the
developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor
(FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity. The Rac1 GTPase
integrates a Wnt-Frizzled-Disheveled axon-stabilizing signal and a Branchless (FGF)-Breathless (FGF receptor) axon-
retracting signal to modulate JNK activity. JNK activity is necessary and sufficient for axon extension, whereas the
antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise
wiring pattern.
Citation: Srahna M, Leyssen M, Choi CM, Fradkin LG, Noordermeer JN, et al. (2006) A signaling
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