有哪些信誉好的足球投注网站a two-gene balance regulates salmonella typhimurium tolerance in the nematode caenorhabditis elegans二基因平衡调节鼠伤寒沙门氏菌线虫线虫的宽容.pdfVIP
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a two-gene balance regulates salmonella typhimurium tolerance in the nematode caenorhabditis elegans二基因平衡调节鼠伤寒沙门氏菌线虫线虫的宽容
A Two-Gene Balance Regulates Salmonella Typhimurium
Tolerance in the Nematode Caenorhabditis elegans
1 2 1
Elizabeth K. Marsh , Maaike C. W. van den Berg , Robin C. May *
1 School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom, 2 Laboratory of Physiological Chemistry, University Medical Center
Utrecht, Utrecht, The Netherlands
Abstract
Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes.
However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the
protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus
neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off
in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine
kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously
thought.
Citation: Marsh EK, van den Berg MCW, May RC (2011) A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis
elegans. PLoS ONE 6(3): e16839. doi:10.1371/journal.pone.0016839
Editor: Matt Kaeberlein, University of Washington, United States of America
Received November 26, 2010; Accepted January 3, 2011; Published March 2, 2011
Copyright: 2011 Marsh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestrict
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