a scan for positively selected genes in the genomes of humans and chimpanzees积极的扫描选定的基因在人类和黑猩猩的基因组.pdfVIP
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Open access, freely available online PLoS BIOLOGY
A Scan for Positively Selected Genes
in the Genomes of Humans and Chimpanzees
1,2* 1 3 4 3
Rasmus Nielsen , Carlos Bustamante , Andrew G. Clark , Stephen Glanowski , Timothy B. Sackton ,
1 1 5 6 6
Melissa J. Hubisz , Adi Fledel-Alon , David M. Tanenbaum , Daniel Civello , Thomas J. White ,
6 5¤ 6
John J. Sninsky , Mark D. Adams , Michele Cargill
1 Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, 2 Center for Bioinformatics, University of Copenhagen,
Denmark, 3 Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America, 4 Applied Biosystems, Rockville, Maryland, United States of
America, 5 Celera Genomics, Rockville, Maryland, United States of America, 6 Celera Diagnostics, Alameda, California, United States of America
Since the divergence of humans and chimpanzees about 5 million years ago, these species have undergone a
remarkable evolution with drastic divergence in anatomy and cognitive abilities. At the molecular level, despite the
small overall magnitude of DNA sequence divergence, we might expect such evolutionary changes to leave a
noticeable signature throughout the genome. We here compare 13,731 annotated genes from humans to their
chimpanzee orthologs to identify genes that show evidence of positive selection. Many of the genes that prese
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