有哪些信誉好的足球投注网站a switch from a gradient to a threshold mode in the regulation of a transcriptional cascade promotes robust execution of meiosis in budding yeast开关从一个梯度阈值模式的监管在出芽酵母转录级联促进减数分裂的可靠执行.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a switch from a gradient to a threshold mode in the regulation of a transcriptional cascade promotes robust execution of meiosis in budding yeast开关从一个梯度阈值模式的监管在出芽酵母转录级联促进减数分裂的可靠执行
A Switch from a Gradient to a Threshold Mode in the
Regulation of a Transcriptional Cascade Promotes
Robust Execution of Meiosis in Budding Yeast
Vyacheslav Gurevich, Yona Kassir*
Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Abstract
Tight regulation of developmental pathways is of critical importance to all organisms, and is achieved by a transcriptional
cascade ensuring the coordinated expression of sets of genes. We aimed to explore whether a strong signal is required to
enter and complete a developmental pathway, by using meiosis in budding yeast as a model. We demonstrate that meiosis
in budding yeast is insensitive to drastic changes in the levels of its consecutive positive regulators (Ime1, Ime2, and Ndt80).
Entry into DNA replication is not correlated with the time of transcription of the early genes that regulate this event. Entry
into nuclear division is directly regulated by the time of transcription of the middle genes, as premature transcription of
their activator NDT80, leads to a premature entry into the first meiotic division, and loss of coordination between DNA
replication and nuclear division. We demonstrate that Cdk1/Cln3 functions as a negative regulator of Ime2, and that ectopic
expression of Cln3 delays entry into nuclear division as well as NDT80 transcription. Because Ime2 functions as a positive
regulator for premeiotic DNA replication and NDT80 transcription, as well as a negative regulator of Cdk/Cln, we suggest
that a double negative feedback loop between Ime2 and Cdk1/Cln3 promotes a bistable switch from the cell cycle to
meiosis. Moreover, our results suggest a regulatory mode switch that ensures robust meiosis as the transcription of the early
meiosis-specific genes responds in a graded mode to Ime1 levels, whereas that of the middle and late genes as well as
initiation of
您可能关注的文档
- a randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in kolkata, india一项随机、安慰剂对照试验的二价杀,全细胞,在成人和儿童口服霍乱疫苗在霍乱流行地区在加尔各答,印度.pdf
- a randomized trial to assess anti-hiv activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel一个随机试验来评估抗艾滋病活动在女性生殖道分泌物和可溶性粘膜免疫的应用替诺福韦凝胶1%.pdf
- a randomized, single-center double-blinded trial on the effects of diltiazem sustained-release capsules in patients with coronary slow flow phenomenon at 6-month follow-up一项随机、单中心双盲试验的影响地尔硫卓缓释胶囊在6个月随访患者的冠状动脉缓慢流动的现象.pdf
- a randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altituderandomly-controlled研究的早期阶段的心脏功能返回平原后短期暴露于高海拔.pdf
- a rapid and highly sensitive method of non radioactive colorimetric in situ hybridization for the detection of mrna on tissue sections快速和高度敏感的非放射性的方法比色检测mrna的原位杂交组织部分.pdf
- a quantitative, non-destructive methodology for habitat characterisation and benthic monitoring at offshore renewable energy developments量化,非破坏性方法栖息地的描述和底栖生物监测海洋可再生能源的发展.pdf
- a rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of salmonella迅速改变肠道流明的毒性基因表达在过渡到组织中促进系统性传播沙门氏菌.pdf
- a rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens一个快速和简单的程序建立人类正常和癌症手术标本的肾原代细胞培养.pdf
- a rapid method for optimizing running temperature of electrophoresis through repetitive on-chip ce operations优化运行温度的快速方法通过重复的片上电泳ce操作.pdf
- a rapid crosstalk of human γδ t cells and monocytes drives the acute inflammation in bacterial infections人类γδt细胞和单核细胞的快速相声驱动器细菌感染的急性炎症.pdf
- a switch from canonical to noncanonical wnt signaling mediates drug resistance in colon cancer cells开关从规范中的wnt信号介导的耐药性结肠癌细胞.pdf
- a survey of qos multicast in ad hoc networksqos多播在ad hoc网络的调查.pdf
- a symmetric region of the hiv-1 integrase dimerization interface is essential for viral replication对称区域的hiv - 1整合酶二聚作用界面是病毒复制所必需的.pdf
- a synthesis of tagging studies examining the behaviour and survival of anadromous salmonids in marine environments标签的合成研究的行为和生存溯河产卵的大马哈鱼在海洋环境中.pdf
- a synthetic chloride channel relaxes airway smooth muscle of the rat合成氯通道松弛气道平滑肌的老鼠.pdf
- a synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells氯化合成氯通道恢复电导在人类囊性纤维化上皮细胞.pdf
- a switch in the control of growth of the wing imaginal disks of manduca sexta一个开关控制增长的翅膀形象manduca sexta磁盘.pdf
- a synthetic hiv-1 subtype c backbone generates comparable pr and rt resistance profiles to a subtype b backbone in a recombinant virus assay合成hiv - 1 c亚型骨干产生类似的公关和rt电阻配置文件a亚型b骨干重组病毒化验.pdf
- a synthetic adjuvant to enhance and expand immune responses to influenza vaccines合成佐剂来增强和扩大对流感疫苗的免疫反应.pdf
- a synthesis of sierran forest biomass management studies and potential effects on water quality内华达山区森林生物量的综合管理研究和潜在的对水质的影响.pdf
文档评论（0）