有哪些信誉好的足球投注网站a new way of identifying biomarkers in biomedical basic-research studies一个新的标志物的生物医学基础研究的研究方法.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a new way of identifying biomarkers in biomedical basic-research studies一个新的标志物的生物医学基础研究的研究方法
A New Way of Identifying Biomarkers in Biomedical
Basic-Research Studies
1 2 3 4
Alexander Yassouridis *, Tonia Ludwig , Axel Steiger , Friedrich Leisch
1 RG Statistics, Max Planck Institute of Psychiatry, Munich, Germany, 2 RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany, 3 RG Endocrinology of
Sleep, Max Planck Institute of Psychiatry, Munich, Germany, 4 Institute for Applied Statistics and Computing, University of Natural Resources and Life Sciences, Vienna,
Austria
Abstract
A simple, nonparametric and distribution free method was developed for quick identification of the most meaningful
biomarkers among a number of candidates in complex biological phenomena, especially in relatively small samples. This
method is independent of rigid model forms or other link functions. It may be applied both to metric and non-metric data
as well as to independent or matched parallel samples. With this method identification of the most relevant biomarkers is
not based on inferential methods; therefore, its application does not require corrections of the level of significance, even in
cases of thousands of variables. Hence, the introduced method is appropriate to analyze and evaluate data of complex
investigations in clinical and pre-clinical basic research, such as gene or protein expressions, phenotype-genotype
associations in case-control studies on the basis of thousands of genes and SNPs (single nucleotide polymorphism), search
of prevalence in sleep EEG-Data, functional magnetic resonance imaging (fMRI) or others.
Citation: Yassouridis A, Ludwig T, Steiger A, Leisch F (2012) A New Way of Identifying Biomarkers in Biomedical Basic-Research Studies. PLoS ONE 7(5): e35741.
doi:10.1371/journal.pone.003574
您可能关注的文档
- a locus on chromosome 5 is associated with dilated cardiomyopathy in doberman pinschers5是染色体上一个位点与扩张型心肌病的杜宾犬品.pdf
- a legionella pneumophila effector protein encoded in a region of genomic plasticity binds to doticm-modified vacuoles嗜肺性军团菌效应蛋白质编码区域的基因组可塑性结合doticm-modified液泡.pdf
- a longitudinal twin study of skewed x chromosome-inactivation纵向的双胞胎研究x chromosome-inactivation倾斜.pdf
- a law of word meaning in dolphin whistle types法律词义的海豚吹口哨类型.pdf
- a live-attenuated hsv-2 icp0？ virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein d subunit vaccine一个减毒活疫苗hsv-2 icp0 病毒引发10到100倍比糖蛋白d亚单位疫苗预防生殖器疱疹.pdf
- a longitudinal study of bcg vaccination in early childhood the development of innate and adaptive immune responses一个纵向研究接种卡介苗疫苗在儿童早期的先天和适应性免疫反应的发展.pdf
- a loser can be a winner comparison of two instance-based learning models in a market entry competition一个失败者可以成为赢家的比较两个基于实例的学习模型在市场准入竞争.pdf
- a longitudinal study of streptococcus pneumoniae carriage in a cohort of infants and their mothers on the thailand-myanmar border肺炎链球菌的纵向研究马车在一群婴儿和母亲thailand-myanmar边界.pdf
- a lon-like protease with no atp-powered unfolding activity没有需要atp提供能量的lon-like蛋白酶展开活动.pdf
- a low concentration of ethanol impairs learning but not motor and sensory behavior in drosophila larvae低浓度的乙醇会损害学习但不运动和感觉在果蝇幼虫行为.pdf
- a new yeast poly(a) polymerase complex involved in rna quality control一个新的酵母保利(a)参与rna聚合酶复杂的质量控制.pdf
- a newly isolated thermostable lipase from bacillus sp.一个新从芽孢杆菌sp分离出耐热性的脂肪酶。.pdf
- a new type of proton coordination in an f1fo-atp synthase rotor ring一种新型的质子协调f1fo-atp合成酶转子环.pdf
- a nomenclature for vertebral fossae in sauropods and other saurischian dinosaurs命名为椎窝在蜥脚类恐龙和其他蜥恐龙.pdf
- a new zearalenone biodegradation strategy using non-pathogenic rhodococcus pyridinivorans k408 strain一个新的玉米烯酮降解策略使用非致病性的红球菌属pyridinivorans k408压力.pdf
- a new model to produce infectious hepatitis c virus without the replication requirement新模式产生感染丙型肝炎病毒的复制要求.pdf
- a non membrane-targeted human soluble cd59 attenuates choroidal neovascularization in a model of age related macular degeneration一个非人类membrane-targeted可溶性cd59变弱脉络膜新生血管形成的与年龄相关的黄斑退行性的典范.pdf
- a non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis斑马鱼端粒酶逆转录酶的非规范函数需要发展造血作用.pdf
- a nonluminescent and highly virulent vibrio harveyi strain is associated with “bacterial white tail disease” of litopenaeus vannamei shrimpnonluminescent和高度致命的鳗弧菌菌株与u201c细菌白尾病u201d方面对虾虾.pdf
- a non-coding rna within the rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans非编码rna在rasgrf1鼠标轨迹是印在反式和由其同源染色体.pdf
文档评论（0）