有哪些信誉好的足球投注网站a longitudinal study of bcg vaccination in early childhood the development of innate and adaptive immune responses一个纵向研究接种卡介苗疫苗在儿童早期的先天和适应性免疫反应的发展.pdfVIP
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a longitudinal study of bcg vaccination in early childhood the development of innate and adaptive immune responses一个纵向研究接种卡介苗疫苗在儿童早期的先天和适应性免疫反应的发展
A Longitudinal Study of BCG Vaccination in Early
Childhood: The Development of Innate and Adaptive
Immune Responses
1,2 2 1 1 2
Yenny Djuardi *, Erliyani Sartono , Heri Wibowo , Taniawati Supali , Maria Yazdanbakhsh
1 Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, 2 Department of Parasitology, Leiden University Medical Center, Leiden, The
Netherlands
Abstract
BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however
recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present
cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD
were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4
years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after
vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly
correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on
innate immune responses in terms of early IL-10 or TNF-a production whereas some alterations in general adaptive immune
responses to PHA were observed.
Citation: Djuardi Y, Sartono E, Wibowo H, Supali T, Yazdanbakhsh M (2010) A Longitudinal Study of BCG Vaccination in Early Childhood: The Development of
Innate and Adaptive Immune Responses. PLoS ONE 5(11): e14066. doi:10.1371/journal.pone.0014066
Editor: Ludovic Tailleux, Institut Pasteur, France
Received July 20, 2010; Accepted October 28, 2010; P
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