a non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis斑马鱼端粒酶逆转录酶的非规范函数需要发展造血作用.pdfVIP

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a non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis斑马鱼端粒酶逆转录酶的非规范函数需要发展造血作用.pdf

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a non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis斑马鱼端粒酶逆转录酶的非规范函数需要发展造血作用

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis 1. 2. 1 3 5 Shintaro Imamura , Junzo Uchiyama , Eriko Koshimizu , Jun-ichi Hanai , Christina Raftopoulou , 4 2 6 4 7 Ryan D. Murphey , Peter E. Bayliss , Yoichi Imai , Caroline Erter Burns , Kenkichi Masutomi , Sarantis 5 4 2 1 Gagos , Leonard I. Zon , Thomas M. Roberts , Shuji Kishi * 1 Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, 4 Stem Cell Program and Division of Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens Greece, Athens, Greece, 6 The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts, United States of America, 7 Cancer Stem Cell Project, National Cancer Center, Tokyo, Japan Abstract Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. To further