a new zearalenone biodegradation strategy using non-pathogenic rhodococcus pyridinivorans k408 strain一个新的玉米烯酮降解策略使用非致病性的红球菌属pyridinivorans k408压力.pdfVIP

A New Zearalenone Biodegradation Strategy Using Non- Pathogenic Rhodococcus pyridinivorans K408 Strain ´ 1 2 ´ 2 ´ ´ ´ 2 ´ 2 ´ 2 Rokus Kriszt , Csilla Krifaton , Sandor Szoboszlay , Matyas Cserhati , Balazs Kriszt , Jozsef Kukolya , ´ ´ ´ 3,4 ´ ´ 3,4 ´ ¨ ¨ 3 3 ´ 1 ´ 5 Arpad Czeh , Szilvia Feher-Toth , Lıvia Torok , Zsuzsanna Szo˝ ke , Krisztina J. Kovacs , Terez Barna , ´ 1* Szilamer Ferenczi 1 Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary, 2 Department of Environmental Protection and Safety, Szent ´ ´ ´ Istvan University, Hungary, 3 Soft Flow Hungary RD Ltd. Pecs, Hungary, 4 University of Pecs, Faculty of Medicine, Department of Biophysics, Pecs, Hungary, 5 Department of Genetics and Applied Microbiology, University of Debrecen, Hungary Abstract Zearalenone (hereafter referred to as ZEA) is a nonsteroidal estrogenic mycotoxin produced by several Fusarium spp. on cereal grains. ZEA is one of the most hazardous natural endocrine disrupting chemicals (EDC) which induces hyper estrogenic responses in mammals. This can result in reproductive disorders in farm animals as well as in humans. Consequently, detoxification strategies for contaminated crops are crucial for food safety. In this study we have developed a bacterial based detoxification