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a new mouse model to explore therapies for preeclampsia一个新的小鼠模型探索治疗子痫前期
A New Mouse Model to Explore Therapies for
Preeclampsia
1. 1. 1 2 1
Abdulwahab Ahmed , Jameel Singh , Ysodra Khan , Surya V. Seshan , Guillermina Girardi *
1 Department of Biology, York College, City University of New York, New York, New York, United States of America, 2 Department of Pathology, Weill Cornell Medical
College, New York, New York, United States of America
Abstract
Background: Pre-eclampsia, a pregnancy-specific multisystemic disorder is a leading cause of maternal and perinatal
mortality and morbidity. This syndrome has been known to medical science since ancient times. However, despite
considerable research, the cause/s of preeclampsia remain unclear, and there is no effective treatment. Development of an
animal model that recapitulates this complex pregnancy-related disorder may help to expand our understanding and may
hold great potential for the design and implementation of effective treatment.
Methodology/Principal Findings: Here we show that the CBA/J x DBA/2 mouse model of recurrent miscarriage is also a
model of immunologically-mediated preeclampsia (PE). DBA/J mated CBA/J females spontaneously develop many features
of human PE (primigravidity, albuminuria, endotheliosis, increased sensitivity to angiotensin II and increased plasma leptin
levels) that correlates with bad pregnancy outcomes. We previously reported that antagonism of vascular endothelial
growth factor (VEGF) signaling by soluble VEGF receptor 1 (sFlt-1) is involved in placental and fetal injury in CBA/J x DBA/2
mice. Using this animal model that recapitulates many of the features of preeclampsia in women, we found that pravastatin
restores angiogenic
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