a new view of the lethal apoptotic pore一个新的视图的致命的凋亡孔隙.pdfVIP

Primer A New View of the Lethal Apoptotic Pore ˜ 1 2 2 Gorka Basanez *, Lucian Soane , J. Marie Hardwick 1 Biophysics Unit, Spanish Science Research Council (CSIC) and University of the Basque Country (UPV/EHU), Bilbao, Spain, 2 Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America pore allows for rapid diffusion out of the mitochondria of Abstract: Cell death by apoptosis is indispensable for cytochrome c and other proteins that promote the irreversible proper development and tissue homeostasis in all dismantling of the cell. Despite intense research efforts, our multicellular organisms, and its deregulation plays a key understanding of the molecular machinery and mechanisms role in cancer and many other diseases. A crucial event in implicated in this crucial aspect of apoptosis is still incomplete. apoptosis is the formation of protein-permeable pores in the outer mitochondrial membrane that release cyto- chrome c and other apoptosis-promoting factors into the BCL-2 Family Proteins Regulate the Apoptotic cytosol. Research efforts over the past two decades have Pore established that apoptotic pores require BCL-2 family BCL-2 family proteins have long been considered the main proteins, with the proapoptotic BAX-type proteins being direct effectors of pore formation. Accumulating evidence