multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of als人类脐带血细胞的多个静脉政府als的小鼠模型中获益.pdfVIP

Multiple Intravenous Administrations of Human Umbilical Cord Blood Cells Benefit in a Mouse Model of ALS 1,2,3,4 1,7 1 1 Svitlana Garbuzova-Davis *, Maria C. O. Rodrigues , Santhia Mirtyl , Shanna Turner , Shazia 1 1 1 1,2 6 Mitha , Jasmine Sodhi , Subatha Suthakaran , David J. Eve , Cyndy D. Sanberg , Nicole Kuzmin- Nichols6, Paul R. Sanberg1,2,4,5 1 Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, United States of America, 2 Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, United States of America, 3 Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, Florida, United States of America, 4 Department of Pathology and Cell Biology, University of South Florida, College of Medicine, Tampa, Florida, United States of America, 5 Department of Psychiatry, University of South Florida, College of Medicine, Tampa, Florida, United ˜ ˜ ˜ States of America, 6 Saneron CCEL Therapeutics, Inc., Tampa, Florida, United States of America, 7 Ribeirao Preto School of Medicine, University of Sao Paulo, Sao Paulo, Brazil Abstract Background: A promising therapeutic strategy for amyotrophic lateral sclerosis (ALS) is the use of cell-based therapies that can protect motor neurons and thereby retard disease progression. We recently showed that a single large dose (2