有哪些信誉好的足球投注网站myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx micemyogenin调节运动能力但可有可无的成人骨骼肌再生的mdx老鼠.pdfVIP
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myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx micemyogenin调节运动能力但可有可无的成人骨骼肌再生的mdx老鼠
Myogenin Regulates Exercise Capacity but Is Dispensable for Skeletal Muscle Regeneration in Adult mdx Mice 1,2. 1,2. 1 Eric Meadows , Jesse M. Flynn , William H. Klein * 1 Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, 2 Graduate Training Program in Genes and Development, The University of Texas School of Biomedical Sciences at Houston, Houston, Texas, United States of America Abstract Duchenne muscular dystrophy (DMD) is the most prevalent inherited childhood muscle disorder in humans. mdx mice exhibit a similar pathophysiology to the human disorder allowing for an in-depth investigation of DMD. Myogenin, a myogenic regulatory factor, is best known for its role in embryonic myogenesis, but its role in adult muscle maintenance and regeneration is still poorly understood. Here, we generated an mdx:Myogflox/flox mouse harboring a tamoxifen-inducible Cre recombinase transgene, which was used to conditionally delete Myog during adult life. After tamoxifen treatment, three groups of mice were created to study the effects of Myog deletion: mdx:Myogflox/flox mice (mdx), Myogflox/flox mice (wild- type), and mdx:MyogfloxD/floxD:Cre-ER mice (mdx:Myog-deleted). mdx:Myog-deleted mice exhibited no adverse phenotype and behaved normally. When run to exhaustion, mdx:Myog-deleted mice demonstrated an enhanced capacity for exercise compared to mdx mice, running nearly as far as wild-type mice. Moreover, these mice showed the same signature characteristics of muscle regeneration as mdx mice. Unexpectedly, we found that myogenin was dispensable for muscle regeneration. Factors associated with muscle fatig
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