有哪些信誉好的足球投注网站monocyte scintigraphy in rheumatoid arthritis the dynamics of monocyte migration in immune-mediated inflammatory disease单核细胞显像在风湿性关节炎单核细胞迁移的动态免疫介导的炎症性疾病.pdfVIP
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monocyte scintigraphy in rheumatoid arthritis the dynamics of monocyte migration in immune-mediated inflammatory disease单核细胞显像在风湿性关节炎单核细胞迁移的动态免疫介导的炎症性疾病
Monocyte Scintigraphy in Rheumatoid Arthritis: The Dynamics of Monocyte Migration in Immune-Mediated Inflammatory Disease 1 1 2 3 3 Rogier M. Thurlings , Carla A. Wijbrandts , Roelof J. Bennink , Serge E. Dohmen , Carlijn Voermans , 4 5 1 2 1 Diana Wouters , Elena S. Izmailova , Danielle M. Gerlag , Berthe L. F. van Eck-Smit , Paul P. Tak * 1 Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Noord Holland, The Netherlands, 2 Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Noord Holland, The Netherlands, 3 Landsteiner Laboratory, Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Noord Holland, The Netherlands, 4 Department of Immunopathology, Sanquin Research, Amsterdam, Noord Holland, The Netherlands, 5 Millennium Pharmaceuticals, Inc, Department of Research and Development, Cambridge, Massachusetts, United States of America Abstract Background: Macrophages are principal drivers of synovial inflammation in rheumatoid arthritis (RA), a prototype immune- mediated inflammatory disease. Conceivably, synovial macrophages are continuously replaced by circulating monocytes in RA. Animal studies from the 1960s suggested that macrophage replacement by monocytes is a slow process in chronic inflammatory lesions. Translation of these data into the human condition has been hampered by the lack of available techniques to analyze monocyte migration in man. Methods/Principal Findings: We developed a technique that enabled us to ana
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