myeloid suppressor cell depletion augments antitumor activity in lung cancer骨髓抑制肺癌细胞损耗增加抗癌活性.pdfVIP

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer 1,4 1,4 4 3 4 4 Minu K. Srivastava , Li Zhu , Marni Harris-White , Upendra Kar , Min Huang , Ming F. Johnson , 1,2 1,2 5 1,2,4 1,2,4 Jay M. Lee , David Elashoff , Robert Strieter , Steven Dubinett , Sherven Sharma * 1 Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 2 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 3 Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 4 Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, 5 Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America Abstract Background: Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer. Principal Findings: Individual antibody mediated depletion of MDSC (anti-Gr1 or anti-Ly6G) enhanced the antitumor activity against lung cancer. In comparison to controls, MDSC depletion enhanced the APC a