有哪些信誉好的足球投注网站myocilin polymorphisms and primary open-angle glaucoma a systematic review and meta-analysismyocilin多态性与原发性开角型青光眼的系统回顾和荟萃分析.pdfVIP
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myocilin polymorphisms and primary open-angle glaucoma a systematic review and meta-analysismyocilin多态性与原发性开角型青光眼的系统回顾和荟萃分析
Myocilin Polymorphisms and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis 1. 2. 1 1 1 3 1 Jin-Wei Cheng , Shi-Wei Cheng , Xiao-Ye Ma , Ji-Ping Cai , You Li , Guo-Cai Lu *, Rui-Li Wei * 1 Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, 2 School of Life Sciences, Ludong University, Yantai, China, 3 Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai, China Abstract Background: Glaucoma is the leading cause of irreversible blindness in the world. Recent evidence indicates a role for genetic susceptibility to primary open-angle glaucoma (POAG). The relation between myocilin polymorphisms and POAG susceptibility has been studied in different populations. Methods: A meta-analysis of 32 published genetic association case-control studies, which examined the relation between POAG and the R46X, R76K, Y347Y, T353I, and Q368X polymorphisms of the myocilin gene, was carried out. Results: In meta-analysis, significant associations were observed between POAG risk and two myocilin polymorphisms with summarized odds ratio of 4.68 (95%CI, 2.02–10.85) for Q368X and 2.17 (95% CI, 1.32–3.57) for T353I. Both Q368X and T353I were significantly associated with high-tension glaucoma, with summarized odds ratio of 4.26 (1.69, 10.73) and 2.26 (1.37– 3.72). In Westerners, significant association was observed for Q368X mutation (odds ratio, 5.17; 95% CI, 2.16–12.40). However, in Asians it was for T353I (odds ratio, 2.17; 95% CI, 1.32–3.57). Conclusions: There is strong evidence that myocilin polymorphisms are associated with POAG suscep
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