有哪些信誉好的足球投注网站monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin muc4 in pancreatic cancer单克隆抗体识别non-tandem重复区域的人类粘蛋白muc4胰腺癌.pdfVIP
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monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin muc4 in pancreatic cancer单克隆抗体识别non-tandem重复区域的人类粘蛋白muc4胰腺癌
Monoclonal Antibodies Recognizing the Non-Tandem Repeat Regions of the Human Mucin MUC4 in Pancreatic Cancer 1 1 1 1 1 Maneesh Jain *, Ganesh Venkatraman , Nicolas Moniaux , Sukhwinder Kaur , Sushil Kumar , Subhankar 1 3 1,2 Chakraborty , Grish C. Varshney , Surinder K. Batra * 1 Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, 2 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, 3 Institute of Microbial Technology, Chandigarh, India Abstract The MUC4 mucin is a high molecular weight, membrane-bound, and highly glycosylated protein. It is a multi-domain protein that is putatively cleaved into a large mucin-like subunit (MUC4a) and a C-terminal growth-factor like subunit (MUC4b). MUC4 plays critical roles in physiological and pathological conditions and is aberrantly overexpressed in several cancers, including those of the pancreas, cervix, breast and lung. It is also a potential biomarker for the diagnosis, prognosis and progression of several malignancies. Further, MUC4 plays diverse functional roles in cancer initiation and progression as evident from its involvement in oncogenic transformation, proliferation, inhibition of apoptosis, motility and invasion, and resistance to chemotherapy in human cancer cells. We have previously generated a monoclonal antibody 8G7, which is directed against the TR region of MUC4, and has been extensively used to study the expression of MUC4 in several malignancies. Here, we describe the gen
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