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myc is required for activation of the atm-dependent checkpoints in response to dna damagemyc的激活需要atm-dependent检查点来响应dna损伤
Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage 1. 2. ¨ 2 2 1 ¨ 3 Lina Guerra , Ami Albihn , Susanna Tronnersjo , Qinzi Yan , Riccardo Guidi , Bo Stenerlow , Torsten 4 4 5 5 1 Sterzenbach , Christine Josenhans , James G. Fox , David B. Schauer , Monica Thelestam , Lars-Gunnar 2,6 2 1 Larsson , Marie Henriksson , Teresa Frisan * 1 Departments of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, 2 Departments of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, 3 Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden, 4 Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany, 5 Department of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 6 Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden Abstract Background: The MYC protein controls cellular functions such as differentiation, proliferation, and apoptosis. In response to genotoxic agents, cells overexpressing MYC undergo apoptosis. However, the MYC-regulated effectors acting upstream of the mitochondrial apoptotic pathway are still unknown. Principal Findings: In this study, we demonstrate that expression of Myc is required to activate the Ataxia telangiectasia mutated (A
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