multiple loci are associated with dilated cardiomyopathy in irish wolfhounds多个位点与扩张型心肌病在爱尔兰猎狼犬.pdfVIP

Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds 1 2 ¨ ¨ 3 4 1 Ute Philipp *, Andrea Vollmar , Jens Haggstrom , Anne Thomas , Ottmar Distl 1 Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany, 2 Veterinary Clinic for Small Animals, Wissen, Germany, 3 Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden, 4 ANTAGENE, Animal Genetics Laboratory, Limonest, France Abstract Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP. ¨ ¨ Citation: Philipp U, Vollmar A, Haggstrom J, Thomas A, Distl O (2012) Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds. PLoS ONE 7(6): e36691. doi:10.1371/journal.pone.0036691 Editor: Rongling Wu, Pennsylvania State University, United States of America Received December 7, 2011; Accepted April 7, 2012; Published June 25, 2012 Copyright: 2012 Philipp et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fu