multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family多个kisspeptin osteichthyans月初受体受体家族的进化提供新的视角.pdfVIP

Multiple Kisspeptin Receptors in Early Osteichthyans Provide New Insights into the Evolution of This Receptor Family ´ ´ 1 ¨ 1 2 1 3 Jeremy Pasquier , Anne-Gaelle Lafont , Shan-Ru Jeng , Marina Morini , Ron Dirks , Guido van den 3 4 ´ 5 6 1 1 Thillart , Jonna Tomkiewicz , Herve Tostivint , Ching-Fong Chang , Karine Rousseau , Sylvie Dufour * ´ 1 Museum National d’Histoire Naturelle, Research Unit BOREA, Biology of Aquatic Organisms and Ecosystems, CNRS 7208- IRD207- UPMC, Paris, France, 2 National Kaohsiung Marine University, Department of Aquaculture, Kaohsiung, Taiwan, 3 Leiden University, ZF-screens B.V. and Institute of Biology, Leiden, The Netherlands, ´ 4 Technical University of Denmark, National Institute of Aquatic Resources, Charlottenlund, Denmark, 5 Museum National d’Histoire Naturelle, UMR 7221 CNRS/MNHN ´ Evolution des Regulations Endocriniennes, Paris, France, 6 National Taiwan Ocean University, Department of Aquaculture and Center of Excellence for Marine Bioenvironment and Biotechnology, Keelung, Taiwan Abstract Deorphanization of GPR54 receptor a decade ago led to the characterization of the kisspeptin receptor (Kissr) in mammals and the discovery of its major role in the brain control of reproduction. While a single gene encodes for Kissr in eutherian mammals including human, other vertebrates present a variable number of Kissr genes, from none in birds, one or two in teleosts, to three in an amphibian, xenopus. In order to