molecular evolution of hiv-1 crf01_ae env in thai patients分子进化的hiv - 1 crf01_ae env在泰国的病人.pdfVIP
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molecular evolution of hiv-1 crf01_ae env in thai patients分子进化的hiv - 1 crf01_ae env在泰国的病人
Molecular Evolution of HIV-1 CRF01_AE Env in Thai Patients 1. 2. 3 3 Samatchaya Boonchawalit , Duangrat Jullaksorn , Jiraporn Uttiyoung , Amara Yowang , Nongkran 4 4 5 6 4 Krathong , Sununta Chautrakul , Akifumi Yamashita , Kazuyoshi Ikuta , Amornsak Roobsoong , 3 2 1,6 Sangkom Kanitvittaya , Pathom Sawanpanyalert , Masanori Kameoka * 1Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi, Thailand, 2 National Institute of Health, Department of Medical Sciences (DMSc), Ministry of Public Health (MOPH), Nonthaburi, Thailand, 3 Regional Medical Science Center Chiangrai, DMSc, MOPH, Chiangrai, Thailand, 4 Mae- Soay Hospital, Chiangrai, Thailand, 5 Graduate School of Life Science, Tohoku University, Miyagi, Japan, 6 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Abstract Background: The envelope glycoproteins (Env), gp120 and gp41, are the most variable proteins of human immunodeficiency virus type 1 (HIV-1), and are the major targets of humoral immune responses against HIV-1. A circulating recombinant form of HIV-1, CRF01_AE, is prevalent throughout Southeast Asia; however, only limited information regarding the immunological characteristics of CRF01_AE Env is currently available. In this study, we attempted to examine the evolutionary pattern of CRF01_AE Env under the se
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