icariside ii induces apoptosis in u937 acute myeloid leukemia cells role of inactivation of stat3-related signalingicariside ii急性骨髓性白血病u937细胞凋亡作用stat3-related信号的失活.pdfVIP

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icariside ii induces apoptosis in u937 acute myeloid leukemia cells role of inactivation of stat3-related signalingicariside ii急性骨髓性白血病u937细胞凋亡作用stat3-related信号的失活.pdf

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icariside ii induces apoptosis in u937 acute myeloid leukemia cells role of inactivation of stat3-related signalingicariside ii急性骨髓性白血病u937细胞凋亡作用stat3-related信号的失活

Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling 1. 1,2. 1 1 1 1 Sang-Hun Kang , Soo-Jin Jeong , Sun-Hee Kim , Ji-Hyun Kim , Ji Hoon Jung , Wonil Koh , 3 4 5 1 Jung Hyo Kim , Dae Keun Kim , Chang-Yan Chen , Sung-Hoon Kim * 1 College of Oriental Medicine, Kyung Hee University, Seoul, South Korea, 2 Basic Herbal Research Group, Korea Institute of Oriental Medicine, Daejeon, South Korea, 3 Chosun Nursing College, Kwangju, South Korea, 4 College of Pharmacy, Woosuk University, Wanju, South Korea, 5 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid leukemia (AML) cell line U937. Methodology/Principal Findings: Icariside II blocked the growth U937 cells in a dose- and time-dependent manner. In this anti-proliferation process, this herb compound rendered the cells susceptible to apoptosis, manifested by enhanced accumulation of sub-G1 cell population and increased the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells. Icariside II was able to activate caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP) in a time- dependent manner. Concurrently, the anti-apoptotic proteins, such as bcl-xL and survivin in U937 cells, were downregulated by Icariside II. In addition, Icariside II could inhibit STAT3 phosphorylation and function and subse