hiv-1hsv-2 co-infected adults in early hiv-1 infection have elevated cd4+ t cell countshiv-1hsv-2感染成人早期hiv - 1感染的cd4 + t细胞计数升高.pdfVIP

HIV-1/HSV-2 Co-Infected Adults in Early HIV-1 Infection Have Elevated CD4+ T Cell Counts 1 4 2 2 2 4 3 Jason D. Barbour , Mariana M. Sauer , Elizabeth R. Sharp , Keith E. Garrison , Brian R. Long , Helena Tomiyama , Katia C. Bassichetto , 3 3 2 4 Solange M. Oliveira , Maria C. Abbate , Douglas F. Nixon , Esper G. Kallas * 1 HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America, ˜ 2 Department of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America, 3 Sao Paulo City ˜ ˜ Health System, Sao Paulo, Brazil, 4 Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil Introduction. HIV-1 is often acquired in the presence of pre-existing co-infections, such as Herpes Simplex Virus 2 (HSV-2). We examined the impact of HSV-2 status at the time of HIV-1 acquisition for its impact on subsequent clinical course, and total CD4+ T cell phenotypes. Methods. We assessed the relationship of HSV-1/HSV-2 co-infection status on CD4+ T cell counts and ¨ HIV-1 RNA levels over time prior in a cohort of 186 treatment naıve adults identified during early HIV-1 infection. We assessed the activation and differentiation state of t