有哪些信誉好的足球投注网站hugl1 and hugl2 in mammary epithelial cells polarity, proliferation, and differentiationhugl1 hugl2乳腺上皮细胞极性,增殖,分化.pdfVIP
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hugl1 and hugl2 in mammary epithelial cells polarity, proliferation, and differentiationhugl1 hugl2乳腺上皮细胞极性,增殖,分化
Hugl1 and Hugl2 in Mammary Epithelial Cells: Polarity, Proliferation, and Differentiation 1 2 1,2,4 1,2,3,4 Atlantis Russ , Jeanne M. V. Louderbough , Daniela Zarnescu , Joyce A. Schroeder * 1 Genetics Interdisciplinary Program, University of Arizona, Tucson, Arizona, United States of America, 2 Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America, 3 Arizona Cancer Center, University of Arizona, Tucson, Arizona, United States of America, 4 BIO5 Institute, University of Arizona, Tucson, Arizona, United States of America Abstract Loss of epithelial polarity is described as a hallmark of epithelial cancer. To determine the role of Hugl1 and Hugl2 expression in the breast, we investigated their localization in human mammary duct tissue and the effects of expression modulation in normal and cancer cell lines on polarity, proliferation and differentiation. Expression of Hugl1 and Hugl2 was silenced in both MCF10A cells and Human Mammary Epithelial Cells and cell lines were grown in 2-D on plastic and in 3-D in Matrigel to form acini. Cells in monolayer were compared for proliferative and phenotypic changes while acini were examined for differences in size, ability to form a hollow lumen, nuclear size and shape, and localization of key domain- specific proteins as a measure of polarity. We detected overlapping but distinct localization of Hugl1 and Hugl2 in the human mammary gland, with Hugl1 expressed in both luminal and myoepithelium and Hugl2 largely restricted to myoepithelium. On a plastic surface, loss of Hugl1 or Hugl2 in normal epitheliu
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