how mammals acquire and distribute iron needed for oxygen-based metabolism哺乳动物是如何获取和分发oxygen-based新陈代谢所需铁.pdfVIP

Primer How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism Tracey A. Rouault irtually all cells and organisms are used to fuel cellular metabolism. Copyright: © 2003 Tracey A. Rouault. This is an require iron to perform Iron also enables hemoglobin in red open-access article distributed under the terms of Vbasic cellular processes. In blood cells to bind and transport the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduc- respiration, iron proteins capture oxygen to tissues throughout the tion in any medium, provided the original work is energy released from oxidation of body. Since iron is indispensable for properly cited. food by synthesizing high-energy respiration and oxygen transport, it is Abbreviation: IRP, iron regulatory protein compounds, such as NADH, that not surprising that cellular acquisition of iron has not been left to chance. It Tracey A. Rouault works for the Cell Biology and Metabolism Branch of the National Institute can be a challenge for organisms to of Child Health and Human Development in Primers provide a concise introduction into an obtain sufficient iron because much Bethesda, Maryland, United States of America. E-mail: important aspect of biology th