high cd8+ t cell activation marks a less differentiated hiv-1 specific cd8+ t cell response that is not altered by suppression of viral replication高cd8 + t细胞活化标志着少分化hiv - 1特定的cd8 + t细胞反应,不是被抑制病毒复制.pdfVIP

High CD8+ T Cell Activation Marks a Less Differentiated HIV-1 Specific CD8+ T Cell Response that Is Not Altered by Suppression of Viral Replication 1 2 2,3 2,3 2,3 Jason D. Barbour *, Lishomwa C. Ndhlovu , Qi Xuan Tan , Terence Ho , Lorrie Epling , Barry M. 2,3{ 1 1 2,3 Bredt , Jay A. Levy , Frederick M. Hecht , Elizabeth Sinclair 1 HIV/AIDS Division, San Francisco General Hospital, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 2 Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 3 UCSF Core Immunology Laboratory, San Francisco General Hospital, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America Abstract Background: The relationship of elevated T cell activation to altered T cell differentiation profiles, each defining features of HIV-1 infection, has not been extensively explored. We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults. Methodology/Principal Findings: We performed a longitudinal study simultaneously measuring T cell activation and maturation markers on both total and antigen-specific T cells in recently infected adu