high expression of nuclear factor 90 (nf90) leads to mitochondrial degradation in skeletal and cardiac muscles核转录因子的高表达90(nf90)会导致骨骼肌肉和心脏肌肉线粒体退化.pdfVIP

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high expression of nuclear factor 90 (nf90) leads to mitochondrial degradation in skeletal and cardiac muscles核转录因子的高表达90(nf90)会导致骨骼肌肉和心脏肌肉线粒体退化.pdf

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high expression of nuclear factor 90 (nf90) leads to mitochondrial degradation in skeletal and cardiac muscles核转录因子的高表达90(nf90)会导致骨骼肌肉和心脏肌肉线粒体退化

High Expression of Nuclear Factor 90 (NF90) Leads to Mitochondrial Degradation in Skeletal and Cardiac Muscles 1. 1 . 2 1 1 Takuma Higuchi , Shuji Sakamoto * , Yoshihiko Kakinuma , Shoko Kai , Ken-ichi Yagyu , 1 1 3 4 1 5 Hiroshi Todaka , Eunsup Chi , Shoshiro Okada , Takako Ujihara , Keiko Morisawa , Masafumi Ono , 1 6 6 7 8 Yasunori Sugiyama , Waka Ishida , Atsuki Fukushima , Masayuki Tsuda , Yasutoshi Agata , Taketoshi Taniguchi1 1 Laboratory of Molecular Biology, Science Research Center, Kochi Medical School, Kochi, Japan, 2 Department of Cardiovascular Control, Kochi Medical School, Kochi, Japan, 3 Department of Pharmacology, Aichi Medical University School of Medicine, Aichi, Japan, 4 The Facility for Radio-isotope Research, Science Research Center, Kochi Medical School, Kochi, Japan, 5 Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan, 6 Department of Ophthalmology, Kochi Medical School, Kochi, Japan, 7 The Division of Laboratory Animal Science, Science Research Center, Kochi Medical School, Kochi, Japan, 8 Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Abstract While NF90 has been known to participate in transcription, translation and microRNA biogenesis, physiological functions of this protein still remain unclear. To uncover this, we generated transgenic (Tg) mice using NF90 cDNA under the control of b-actin promoter. The NF90 Tg mice exhibited a reduction in body weight compared with w