有哪些信誉好的足球投注网站hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes a meta-analysis三widely-evaluated hematopoietically-expressed同源框基因多态性和糖尿病的风险分析.pdfVIP
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hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes a meta-analysis三widely-evaluated hematopoietically-expressed同源框基因多态性和糖尿病的风险分析
Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis Xiaobo Li1,2,3., Yuqiong Li1,2,3., Bei Song1,3., Shujie Guo1,3, Shaoli Chu2,3, Nan Jia2,3*, Wenquan Niu1,3* 1 State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2 Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3 Shanghai Institute of Hypertension, Shanghai, China Abstract Background: The hematopoietically-expressed homeobox (HHEX) gene is identified as a promising candidate for type 2 diabetes by genome-wide association studies, triggering plenty of subsequent replications; however, the results are conflicting. We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk. Methodology/Principal Findings: A random-effects model was adopted irrespective of heterogeneity. Data and study quality were assessed in duplicate. There were 49 studies (cases/controls: 57931/74658) for rs1111875, 18 studies (18227/ 30366) for rs5015480 and 26 studies (25725/30579) for rs7923837, respectively. Overall analyses indicated that rs1111875-C allele (odds ratio [OR] = 1.16; 95% confidence interval [CI]: 1.13–1.2; P,0.0005), rs5015480-C allele (OR = 1.16; 95% CI: 1.06– 1.26; P = 0.001) and rs7923837-G allele (OR = 1.18; 95% CI: 1.12–1.24; P,0.0005) conferred significantly increased risk for type 2 diabetes, yet accompanying moderate to strong evidence of heterogeneity. Despite vast divergence in allele distributions, subgroup analyses by ethnicity showed comparable risk estimates between Asians and Caucasians for three examined polymorphisms. Moreover, results of studies with hospital-based controls deviated greatly from that of a
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