有哪些信誉好的足球投注网站heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationheparanase促进移植和防止在干细胞移植移植物抗宿主病.pdfVIP
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heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationheparanase促进移植和防止在干细胞移植移植物抗宿主病
Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation 1¤ 1 1 2 1 3 Menachem Bitan , Lola Weiss , Michael Zeira , Eyal Zcharia , Shimon Slavin , Arnon Nagler , Israel Vlodavsky4* 1 Department of Bone Marrow Transplantation, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2 Department of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 3 The Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel, 4 Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel Abstract Background: Heparanase, endoglycosidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans, plays important roles in cancer metastasis, angiogenesis and inflammation. Design and Methods: Applying a mouse model of bone marrow transplantation and transgenic mice over-expressing heparanase, we evaluated the effect of heparanase on the engraftment process and the development of graft-versus-host disease. Results: Analysis of F1 mice undergoing allogeneic bone marrow transplantation from C57BL/6 mice demonstrated a better and faster engraftment in mice receiving cells from donors that were pretreated with heparanase. Moreover, heparanase treated recipient F1 mice showed only a mild appearance of graft-versus-host disease and died 27 days post transplantation while control mice rapidly developed signs of graft-versus-host disease (i.e., weight loss, hair loss, diarrhea) and died after 12 days, indicating a protective effect of heparanase against graft-versus-host disease. Similarly, we applied transgenic mice over-expressing heparanase in most t
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