hepatic gene expression profile in mice perorally infected with echinococcus multilocularis eggs小鼠的肝脏基因表达谱口周围的感染棘球绦虫multilocularis鸡蛋.pdfVIP

Hepatic Gene Expression Profile in Mice Perorally Infected with Echinococcus multilocularis Eggs 1 2 1 3 2 ¨ 1 Bruno Gottstein *, Matthias Wittwer , Marc Schild , Michael Merli , Stephen L. Leib , Norbert Muller , ¨ 1, Rolf Jaggi4 Joachim Muller 1Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland, 2 Faculty of Medicine, Institute for Infectious Diseases, University of Bern, Bern, Switzerland, 3 Department of Parasitology, University of Hohenheim, Stuttgart, Germany, 4 Faculty of Medicine, Department of Clinical Research, University of Bern, Bern, Switzerland Abstract Background: Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (.90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown. Methodology/Principal Findings: We used a mouse model of AE to assess gene expression profiles in the liver after establishment of a chronic disease status as a result of a primary peroral infection with eggs of the fox tapeworm Echinococcus multilocularis. Among 38 genes differentially regulated (false discovery rate adjusted p#0.05), 35 genes were assigned to the functional gene ontology group ,immune response., while 3 associated with the functional group ,intermediary metabolism.. Upregulated g