hiv-1 group m conserved elements vaccinehiv - 1 m组元素守恒的疫苗.pdfVIP

Opinions HIV-1 Group M Conserved Elements Vaccine * Morgane Rolland, David C. Nickle, James I. Mullins ecent HIV vaccine designs have sought to block viral corroborate the amount of polymorphisms that can typically escape pathways by compressing antigenic diversity. be accommodated in each protein, as also hinted by a study of RIn light of HIV’s propensity to mutate and thereby to env V3 arguing for site-specific amino acid (AA) conservation ever ramify viral populations, could it be that providing as a predictor of viral fitness [15]. sufficient protection against global diversity is an As HIV-1 establishes infection, it relentlessly mutates away insurmountable problem? We propose an alternative HIV-1 from the founding strain [16]. However, some mutations vaccine design that deliberately includes viral segments recover consensus-like AAs [14,17,18], and these transitions to conserved across the entire main group (or M group) of HIV- ancestral states may reverse CTL escape mutations back to 1 strains and excludes variable segments. We describe a susceptible and possibly increasingly fit forms upon prototype conserved elements (CE) vaccine constituted of 45 transmission to human leukocyte antigen (HLA)-mismatched viral segments at least eight amino acids long that fulfill individuals [10,11,18,19,20]. stringent conservation criteria. HIV-19s predilection to mutate away from CTL-susceptible Our paradigm contends that the best way to cope with sequences highlights the critical importance of CTL HIV-1 diversity may be to avoid it altogether. We argue that a