high hepatitis b surface antigen levels predict insignificant fibrosis in hepatitis b e antigen positive chronic hepatitis b乙型肝炎表面抗原水平高预测无关紧要的纤维化在慢性乙型肝炎乙型肝炎e抗原阳性.pdfVIP

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2017-09-01 发布于上海
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high hepatitis b surface antigen levels predict insignificant fibrosis in hepatitis b e antigen positive chronic hepatitis b乙型肝炎表面抗原水平高预测无关紧要的纤维化在慢性乙型肝炎乙型肝炎e抗原阳性.pdf

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high hepatitis b surface antigen levels predict insignificant fibrosis in hepatitis b e antigen positive chronic hepatitis b乙型肝炎表面抗原水平高预测无关紧要的纤维化在慢性乙型肝炎乙型肝炎e抗原阳性

High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B 1 1 1 2 1 Wai-Kay Seto , Danny Ka-Ho Wong , James Fung , Philip P. C. Ip , John Chi-Hang Yuen , Ivan Fan- Ngai Hung1, Ching-Lung Lai1,3, Man-Fung Yuen1,3* 1 Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong, 2 Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong, 3 State Key Laboratory for Liver Research, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Abstract Introduction: There is no data on the relationship between hepatitis B surface antigen (HBsAg) levels and liver fibrosis in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB). Methods: Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed. The upper limit of normal (ULN) of alanine aminotransferase (ALT) was 30 and 19 U/L for men and women respectively. Histologic assessment was based on Ishak fibrosis staging for fibrosis and Knodell histologic activity index (HAI) for necroinflammation. Results: 140 patients (65% male, median age 32.7 years) were recruited. 56 (40%) had ALT #2 6ULN. 72 (51.4%) and 42 (30%) had fibrosis score #1 and necroinflammation grading #4 respectively. Patients with fibrosis score #1, when compared to patients with fibrosis score .1, had significantly higher median HBsAg levels (50,320 and 7,820 IU/mL respectively, p,0.001). Among patients with ALT #2 6ULN, serum HBsAg levels achieved an area under receiver operating characteristic curve of 0.869 in predicting fibrosis score #1. HBsAg levels did not accurately pred