有哪些信誉好的足球投注网站hif–vegf pathways are critical for chronic otitis media in junbo and jeff mouse mutantshif-vegf途径至关重要的慢性中耳炎junbo和杰夫老鼠突变体.pdfVIP
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hif–vegf pathways are critical for chronic otitis media in junbo and jeff mouse mutantshif-vegf途径至关重要的慢性中耳炎junbo和杰夫老鼠突变体
HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants 1,2 1 1 2 2 Michael T. Cheeseman *, Hayley E. Tyrer , Debbie Williams , Tertius A. Hough , Paras Pathak , Maria R. 1 1 1 1 2 2 2 Romero , Helen Hilton , Sulzhan Bali , Andrew Parker , Lucie Vizor , Tom Purnell , Kate Vowell , Sara 2 1,3 1 1 Wells , Mahmood F. Bhutta , Paul K. Potter , Steve D. M. Brown 1 MRC Mammalian Genetics Unit, MRC Harwell, Harwell, United Kingdom, 2 Mary Lyon Centre, MRC Harwell, Harwell, United Kingdom, 3 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom Abstract Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgical procedure in children and the best treatment for chronic OME, but the mechanism by which they work remains uncertain. As hypoxia is a common feature of inflamed microenvironments, moderation of hypoxia may be a significant contributory mechanism. We have investigated the occurrence of hypoxia and hypoxia-inducible factor (HIF) mediated responses in Junbo and Jeff mouse mutant models, which develop spontaneous chronic otitis media. We found that Jeff and Junbo mice labeled in vivo with pimonidazole showed cellular hypoxia in inflammatory cells in the bulla lumen, and in Junbo the middle ear mucosa w
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