glucose-6-phosphate dehydrogenase deficiency in an endemic area for malaria in manaus a cross-sectional survey in the brazilian amazonglucose-6-phosphate脱氢酶缺乏症在疟疾流行地区在玛瑙斯在巴西亚马逊河的横断面调查.pdfVIP

Glucose-6-Phosphate Dehydrogenase Deficiency in an Endemic Area for Malaria in Manaus: A Cross-Sectional Survey in the Brazilian Amazon 1 ´ ˜ 1,2,3 1,2,3 Marli Stela Santana *, Marcus Vinıcius Guimaraes de Lacerda *, Maria das Grac¸as Vale Barbosa , Wilson Duarte Alecrim2,3, Maria das Grac¸as Costa Alecrim1,3 1 University of the State of Amazonas, Manaus, Amazonas, Brazil, 2 Tropical Medicine Foundation of Amazonas, Manaus, Amazonas, Brazil, 3 Nilton Lins Universitary Center, Manaus, Amazonas, Brazil Abstract Background: There is a paucity of information regarding glucose-6-phosphate dehydrogenase (G6PD) deficiency in endemic areas for malaria in Latin America. Methodology/Principal Findings: This study determined the prevalence of the G6PD deficiency in 200 male non- consanguineous individuals residing in the Ismail Aziz Community, on the outskirts of Manaus (Brazilian Amazon). Six individuals (3%) were deficient using the qualitative Brewer’s test. Gel electrophoresis showed that five of these patients were G6PD A2. The deficiency was not associated with the ethnic origin (P = 0.571). In a multivariate logistic regression analysis, G6PD deficiency protected against three or more episodes of malaria (P = 0.049), independently of the age, and was associated with a history of jaundice (P = 0.020) and need of blood transfusion (P = 0.045) during previous treatment for malarial infection, independently of the age and the previous malarial exposure. Conclusions/Significance: The frequency of G6PD deficiency was similar to other studies performed in Bra