genome-wide hypomethylation in head and neck cancer is more pronounced in hpv-negative tumors and is associated with genomic instability在头部和颈部癌症全基因组hypomethylation hpv-negative肿瘤更明显,与基因组不稳定性相关.pdfVIP

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genome-wide hypomethylation in head and neck cancer is more pronounced in hpv-negative tumors and is associated with genomic instability在头部和颈部癌症全基因组hypomethylation hpv-negative肿瘤更明显,与基因组不稳定性相关.pdf

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genome-wide hypomethylation in head and neck cancer is more pronounced in hpv-negative tumors and is associated with genomic instability在头部和颈部癌症全基因组hypomethylation hpv-negative肿瘤更明显,与基因组不稳定性相关

Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability 1,4¤a 1 2,5 1¤b 7 Kristy L. Richards , Baili Zhang , Keith A. Baggerly , Stefano Colella , James C. Lang , David E. Schuller7, Ralf Krahe1,3,5,6* 1 Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, 2 Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, 3 Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, 4 Division of Cancer Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, 5 Graduate Program in Human and Molecular Genetics, University of Texas at Houston Graduate School in Biomedical Sciences, Houston, Texas, United States of America, 6 Graduate Program in Genes and Development, University of Texas at Houston Graduate School in Biomedical Sciences, Houston, Texas, United States of America, 7 Molecular Biology and Cancer Genetics Programs, Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, United States of America Abstract Loss of genome-wide methylation is a common feature of cancer, and the degree of hypomethylation has been correlated with genomic instability. Global methylation of repetitive elements possibly arose as a defense mechanism against parasitic DNA elements, including retrotransposons and viral pathogens. Given the alterations of global methylation in both viral infection and cancer, we examined genome-wide methylation levels in head