global dissemination of a single mutation conferring white pericarp in rice全球传播单一突变赋予白色果皮大米.pdfVIP

Global Dissemination of a Single Mutation Conferring White Pericarp in Rice 1 2,3 4 5 6 Megan T. Sweeney , Michael J. Thomson , Yong Gu Cho , Yong Jin Park , Scott H. Williamson , 6 1* Carlos D. Bustamante , Susan R. McCouch ˜ 1 Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York, United States of America, 2 International Rice Research Institute, Los Banos, Philippines, 3 Indonesian Center for Agricultural Biotechnology and Genetic Resources Research and Development, Bogor, Indonesia, 4 Department of Agronomy, Chungbuk National University, Chongju, Republic of Korea, 5 National Institute of Agricultural Biotechnology, Suwon, Republic of Korea, 6 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America Here we report that the change from the red seeds of wild rice to the white seeds of cultivated rice (Oryza sativa) resulted from the strong selective sweep of a single mutation, a frame-shift deletion within the Rc gene that is found in 97.9% of white rice varieties today. A second mutation, also within Rc, is present in less than 3% of white accessions surveyed. Haplotype analysis revealed that the predominant mutation originated in the japonica subspecies and crossed both geographic and sterility barriers to move into the indica subspecies. A little less than one Mb of japonica DNA hitchhiked with the rc allele into most indica varieties, suggesting that other linked domestication alleles may have been transferred from japonica to indica along