有哪些信誉好的足球投注网站genome-wide gene amplification during differentiation of neural progenitor cells in vitro全基因组基因在分化的神经祖细胞体外扩增.pdfVIP
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genome-wide gene amplification during differentiation of neural progenitor cells in vitro全基因组基因在分化的神经祖细胞体外扩增
Genome-Wide Gene Amplification during Differentiation of Neural Progenitor Cells In Vitro Ulrike Fischer*, Andreas Keller, Meike Voss, Christina Backes, Cornelius Welter, Eckart Meese Department of Human Genetics, Saarland University, Homburg/Saar, Germany Abstract DNA sequence amplification is a phenomenon that occurs predictably at defined stages during normal development in some organisms. Developmental gene amplification was first described in amphibians during gametogenesis and has not yet been described in humans. To date gene amplification in humans is a hallmark of many tumors. We used array-CGH (comparative genomic hybridization) and FISH (fluorescence in situ hybridization) to discover gene amplifications during in vitro differentiation of human neural progenitor cells. Here we report a complex gene amplification pattern two and five days after induction of differentiation of human neural progenitor cells. We identified several amplified genes in neural progenitor cells that are known to be amplified in malignant tumors. There is also a striking overlap of amplified chromosomal regions between differentiating neural progenitor cells and malignant tumor cells derived from astrocytes. Gene amplifications in normal human cells as physiological process has not been reported yet and may bear resemblance to developmental gene amplifications in amphibians and insects. Citation: Fischer U, Keller A, Voss M, Backes C, Welter C, et al. (2012) Genome-Wide Gene Amplification during Differentiation of Neural Progenitor Cells In Vitro. PLoS ONE 7(5): e37422. doi:10.1371/journal.pone.0037422 Editor: Joseph Najbauer, City of Hope National Medical Center and Beckman Research Institute, United States of America Received January 10, 2012; Accepted April 19, 2012; Published May 14, 2012 Copyright:
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