有哪些信誉好的足球投注网站generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after tha通用规则mechano-regulation结合主题特定的装载条件可以解释骨适应在那之后.pdfVIP
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generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after tha通用规则mechano-regulation结合主题特定的装载条件可以解释骨适应在那之后
Generic Rules of Mechano-Regulation Combined with Subject Specific Loading Conditions Can Explain Bone Adaptation after THA . . . ¨ Tomasz D. Szwedowski , William R. Taylor* , Markus O. Heller , Carsten Perka, Michael Muller, Georg N. Duda ´ ¨ Julius Wolff Institute (JWI), Center for Musculoskeletal Surgery (CMSC), Center for Sports Science and Sports Medicine Berlin (CSSB), Charite – Universitatsmedizin Berlin, Berlin, Germany Abstract Bone adaptation after total hip arthroplasty is associated with the change in internal load environment, and can result in compromised bone stock, which presents a considerable challenge should a revision procedure be required. Under the assumption of a generic mechano-regulatory algorithm for governing bone adaptation, the aim of this study was to understand the contribution of subject specific loading conditions towards explaining the local periprosthetic remodelling variations in patients. CT scans of 3 consecutive THA patients were obtained and used for the construction of subject specific finite element models using verified musculoskeletal loading and physiological boundary conditions. Using either strain energy density or equivalent strain as mechano-transduction signals, predictions of bone adaptation were compared to DEXA derived BMD changes from 7 days to 12 months post-implantation. Individual changes in BMD of up to 33.6% were observed within the 12 month follow-up period, together with considerable inter-patient variability of up to 26%. Estimates of bone adapta
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